Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/36755| Title: | An insight into the synthesis of cationic porphyrin-imidazole derivatives and their photodynamic inactivation efficiency against Escherichia coli |
| Author: | Moreira, Xavier Santos, Patrícia Faustino, M. Amparo F. Raposo, M. Manuela M. Costa, Susana P.G. Moura, Nuno M.M. Gomes, Ana T.P.C. Almeida, Adelaide Neves, M.G.P.M.S. |
| Keywords: | Porphyrin N-Heterocycles Photosensitizer Antimicrobial photodynamic therapy Gram-negative E. coli |
| Issue Date: | Jul-2020 |
| Publisher: | Elsevier |
| Abstract: | New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetero)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a–d were capable to produce cytotoxic species. These photosensitizers were able to photoinactivate Eschericha coli and their inactivation profile was improved in the presence of KI. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10773/36755 |
| DOI: | 10.1016/j.dyepig.2020.108330 |
| ISSN: | 0143-7208 |
| Appears in Collections: | CESAM - Artigos DBio - Artigos DQ - Artigos REQUIMTE - Artigos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| An insight into the synthesis of cationic porphyrin-imidazole derivatives and their.pdf | 1.27 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.