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http://hdl.handle.net/10773/27161
Title: | Toxicity and genotoxicity of organic and inorganic nanoparticles to the bacteria Vibrio fischeri and Salmonella typhimurium |
Author: | Lopes, I. Ribeiro, R. Antunes, F. E. Rocha-Santos, T. A. P. Rasteiro, M. G. Soares, A. M. V. M. Gonçalves, F. Pereira, R. |
Keywords: | Microtox test Ames test Nanoparticles Zeta potential DLS |
Issue Date: | Apr-2012 |
Publisher: | Springer |
Abstract: | The present work aimed at evaluating the toxicity and genotoxicity of two organic (vesicles composed of sodium dodecyl sulphate/didodecyl dimethylammonium bromide-SDS/DDAB and of monoolein and sodium oelate-Mo/NaO) and four inorganic (titanium oxide-TiO₂, silicon titanium-TiSiO₄, Lumidot-CdSe/ZnS, and gold nanorods) nanoparticles (NP), suspended in two aqueous media (Milli Q water and American Society for Testing and Materials (ASTM) hardwater), to the bacteria Vibrio fischeri (Microtox test) and Salmonella typhimurium-his⁻ (Ames test with strains TA98 and TA100). Aiming a better understanding of these biological responses physical and chemical characterization of the studied NP suspensions was carried out. Results denoted a high aggregation state of the NP in the aqueous suspensions, with the exception of SDS/DDAB and Mo/NaO vesicles, and of nanogold suspended in Milli Q water. This higher aggregation was consistent with the low values of zeta potential, revealing the instability of the suspensions. Regarding toxicity data, except for nano TiO₂, the tested NP significantly inhibited bioluminescence of V. fischeri. Genotoxic effects were only induced by SDS/DDAB and TiO₂ for the strain TA98. A wide range of toxicity responses was observed for the six tested NP, differing by more than 5 orders of magnitude, and suggesting different modes of action of the tested NP. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/27161 |
DOI: | 10.1007/s10646-011-0808-9 |
ISSN: | 0963-9292 |
Appears in Collections: | CESAM - Artigos DBio - Artigos DQ - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Lopes et al. - 2012 - Toxicity and genotoxicity of organic and inorganic.pdf | 342.9 kB | Adobe PDF |
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