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http://hdl.handle.net/10773/23941
Título: | Differential gene expression in Iberian green frogs (Pelophylax perezi) inhabiting a deactivated uranium mine |
Autor: | Marques, Sérgio M. Chaves, Sandra Gonçalves, Fernando Pereira, Ruth |
Palavras-chave: | Differential gene expression Iberian green frogs Metals Pelophylax perezi SSH Uranium mine |
Data: | 2013 |
Editora: | Elsevier |
Resumo: | Iberian green frogs (Pelophylax perezi) were found inhabiting a deactivated uranium mine, especially an effluent pond, seriously contaminated with metals and radionuclides. These animals were previously assessed for oxidative stress parameters and did not revealed significant alterations. In order to better understand which mechanisms may be involved in the ability to withstand permanent contamination gene expression analysis was performed in the liver, through suppression subtractive hybridization (SSH). The SSH outcome in the liver revealed the up-regulation of genes coding for the ribosomal protein L7a and for several proteins typical from blood plasma: fibrinogen, hemoglobin and albumin. Besides their normal function, some of these proteins can play an important role as protective agents against oxidative stress. This work provides new insights on possible basal protection mechanisms that may act in organisms exposed chronically to contamination. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/23941 |
DOI: | 10.1016/j.ecoenv.2012.10.010 |
ISSN: | 0147-6513 |
Aparece nas coleções: | CESAM - Artigos DBio - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Marques et al. - 2013 - Differential gene expression in Iberian green frog.pdf | 214.58 kB | Adobe PDF |
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