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DC Field | Value | Language |
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dc.contributor.author | Marques, Sérgio M. | pt_PT |
dc.contributor.author | Chaves, Sandra | pt_PT |
dc.contributor.author | Gonçalves, Fernando | pt_PT |
dc.contributor.author | Pereira, Ruth | pt_PT |
dc.date.accessioned | 2018-08-23T11:28:05Z | - |
dc.date.available | 2018-08-23T11:28:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0147-6513 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10773/23941 | - |
dc.description.abstract | Iberian green frogs (Pelophylax perezi) were found inhabiting a deactivated uranium mine, especially an effluent pond, seriously contaminated with metals and radionuclides. These animals were previously assessed for oxidative stress parameters and did not revealed significant alterations. In order to better understand which mechanisms may be involved in the ability to withstand permanent contamination gene expression analysis was performed in the liver, through suppression subtractive hybridization (SSH). The SSH outcome in the liver revealed the up-regulation of genes coding for the ribosomal protein L7a and for several proteins typical from blood plasma: fibrinogen, hemoglobin and albumin. Besides their normal function, some of these proteins can play an important role as protective agents against oxidative stress. This work provides new insights on possible basal protection mechanisms that may act in organisms exposed chronically to contamination. | pt_PT |
dc.description.sponsorship | Authors wish to acknowledge EDM for their collaboration. Sérgio M. Marques was supported by a PhD grant (Ref. SFRH/BD/38282/2007) from Fundação para a Ciência e Tecnologia (Portuguese Ministry of Science, Technology and Higher Education). This research is part of the projects Engenur (Ref. PTDC/AAC-AMB/114057/2009) funded by the Portuguese Government (Program Ciência - Inovação 2010) and by the European Social Fund. This research was also partially funded by FSE and POPH funds (Programa Ciência 2007). | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F38282%2F2007/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/114057/PT | pt_PT |
dc.rights | restrictedAccess | pt_PT |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | Differential gene expression | pt_PT |
dc.subject | Iberian green frogs | pt_PT |
dc.subject | Metals | pt_PT |
dc.subject | Pelophylax perezi | pt_PT |
dc.subject | SSH | pt_PT |
dc.subject | Uranium mine | pt_PT |
dc.title | Differential gene expression in Iberian green frogs (Pelophylax perezi) inhabiting a deactivated uranium mine | pt_PT |
dc.type | article | pt_PT |
dc.description.version | published | pt_PT |
dc.peerreviewed | yes | pt_PT |
degois.publication.firstPage | 115 | pt_PT |
degois.publication.lastPage | 119 | pt_PT |
degois.publication.title | Ecotoxicology and Environmental Safety | pt_PT |
degois.publication.volume | 87 | pt_PT |
dc.identifier.doi | 10.1016/j.ecoenv.2012.10.010 | pt_PT |
dc.identifier.essn | 1090-2414 | pt_PT |
Appears in Collections: | CESAM - Artigos DBio - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Marques et al. - 2013 - Differential gene expression in Iberian green frog.pdf | 214.58 kB | Adobe PDF |
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