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http://hdl.handle.net/10773/23931
Título: | Coral aquaculture to support drug discovery |
Autor: | Leal, Miguel C. Calado, Ricardo Sheridan, Christopher Alimonti, Andrea Osinga, Ronald |
Palavras-chave: | Bioactive compounds Biomass supply Cnidaria Economic feasibility Microbiota |
Data: | 2013 |
Editora: | Elsevier |
Resumo: | Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolites. The ex hospite culture of coral symbiotic microbiota is extremely challenging and only limited examples of successful culture exist today. By contrast, in toto aquaculture of corals is a commonly applied technology to produce corals for aquaria. Here, we suggest that coral aquaculture could as well be a viable and economically feasible option to produce the biomass required to execute the first steps of the NP-based drug discovery pipeline. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/23931 |
DOI: | 10.1016/j.tibtech.2013.06.004 |
ISSN: | 0167-7799 |
Aparece nas coleções: | CESAM - Artigos DBio - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Leal et al. - 2013 - Coral aquaculture to support drug discovery.pdf | 2.58 MB | Adobe PDF |
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