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DC Field | Value | Language |
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dc.contributor.author | Leal, Miguel C. | pt_PT |
dc.contributor.author | Calado, Ricardo | pt_PT |
dc.contributor.author | Sheridan, Christopher | pt_PT |
dc.contributor.author | Alimonti, Andrea | pt_PT |
dc.contributor.author | Osinga, Ronald | pt_PT |
dc.date.accessioned | 2018-08-22T10:21:24Z | - |
dc.date.available | 2018-08-22T10:21:24Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0167-7799 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10773/23931 | - |
dc.description.abstract | Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolites. The ex hospite culture of coral symbiotic microbiota is extremely challenging and only limited examples of successful culture exist today. By contrast, in toto aquaculture of corals is a commonly applied technology to produce corals for aquaria. Here, we suggest that coral aquaculture could as well be a viable and economically feasible option to produce the biomass required to execute the first steps of the NP-based drug discovery pipeline. | pt_PT |
dc.description.sponsorship | M.C.L. was supported by a PhD scholarship (SFRH/BD/63783/2009) funded by the Fundação para a Ciência e Tecnologia (QREN-POPH-Type 4.1–Advanced Training, subsidized by the European Social Fund and national funds MCTES). C.S. was supported by a research fellowship from the National Fund for Scientific Research (FNRS; F3/5/5-A2/5-MCF/DM-A115). We thank Bruno Jesus for providing the picture used in Figure 1B, and also thank two anonymous reviewers and the Editor for comments and suggestions to improve the manuscript. | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F63783%2F2009/PT | pt_PT |
dc.rights | restrictedAccess | pt_PT |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | Bioactive compounds | pt_PT |
dc.subject | Biomass supply | pt_PT |
dc.subject | Cnidaria | pt_PT |
dc.subject | Economic feasibility | pt_PT |
dc.subject | Microbiota | pt_PT |
dc.title | Coral aquaculture to support drug discovery | pt_PT |
dc.type | article | pt_PT |
dc.description.version | published | pt_PT |
dc.peerreviewed | yes | pt_PT |
degois.publication.firstPage | 555 | pt_PT |
degois.publication.issue | 10 | pt_PT |
degois.publication.lastPage | 561 | pt_PT |
degois.publication.title | Trends in Biotechnology | pt_PT |
degois.publication.volume | 31 | pt_PT |
dc.identifier.doi | 10.1016/j.tibtech.2013.06.004 | pt_PT |
dc.identifier.essn | 1879-3096 | pt_PT |
Appears in Collections: | CESAM - Artigos DBio - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Leal et al. - 2013 - Coral aquaculture to support drug discovery.pdf | 2.58 MB | Adobe PDF |
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