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http://hdl.handle.net/10773/37736
Título: | Robocasting of Cu2+ & La3+ doped sol-gel glass scaffolds with greatly enhanced mechanical properties: compressive strength up to 14 MPa |
Autor: | Ben-Arfa, Basam A. E. Neto, Sofia Miranda Salvado, Isabel M. Pullar, Robert C. Ferreira, José M. F. |
Palavras-chave: | Sol-gel Bioactive glass Compressive strength Particle size distribution Lanthanum ions Copper ions |
Data: | 15-Mar-2019 |
Editora: | Elsevier |
Resumo: | This research details the successful fabrication of scaffolds by robocasting from high silica sol-gel glass doped with Cu2+ or La3+. The parent HSSGG composition within the system SiO2-CaO-Na2O-P2O5 [67% Si - 24% Ca - 5% Na - 4% P (mol%)] was doped with 5 wt% Cu2+ or La3+ (Cu5 and La5). The paper sheds light on the importance of copper and lanthanum in improving the mechanical properties of the 3-D printed scaffolds. 1 h wet milling was sufficient to obtain a bioglass powder ready to be used in the preparation of a 40 vol% solid loading paste suitable for printing. Moreover, Cu addition showed a small reduction in the mean particle size, while La exhibited a greater reduction, compared with the parent glass. Scaffolds with macroporosity between 300 and 500 µm were successfully printed by robocasting, and then sintered at 800 °C. A small improvement in the compressive strength (7-18%) over the parent glass accompanied the addition of La. However, a much greater improvement in the compressive strength was observed with Cu addition, up to 221% greater than the parent glass, with compressive strength values of up to ∼14 MPa. This enhancement in compressive strength, around the upper limit registered for human cancellous bones, supports the potential use of this material in biomedical applications. STATEMENT OF SIGNIFICANCE: 3D porous bioactive glass scaffolds with greatly improved compressive strength were fabricated by robocasting from a high silica sol-gel glasses doped with Cu2+ or La3+. In comparison to the parent glass, the mechanical performance of scaffolds was greatly improved by copper-doping (>220%), while a modest increase of ∼9% was registered for lanthanum-doping. Doping ions (particularly La3+) acted as glass modifiers leading to less extents of silica polymerisation. This favoured the milling of the glass powders and the obtaining of smaller mean particle sizes. Pastes with a high solid loading (40 vol%) and with suitable rheological properties for robocasting were prepared from all glass powders. Scaffolds with dimensions of 3 × 3 × 4 mm and macro-pore sizes between 300 and 500 µm were fabricated. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/37736 |
DOI: | 10.1016/j.actbio.2019.01.048 |
ISSN: | 1742-7061 |
Aparece nas coleções: | CICECO - Artigos DEMaC - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Robocasting of Cu2+ & La3+ doped sol–gel glass scaffolds with greatly enhanced.pdf | 2.01 MB | Adobe PDF | Ver/Abrir |
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