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http://hdl.handle.net/10773/37412
Title: | Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans |
Author: | Vilela, Carla Oliveira, Helena Almeida, Adelaide Silvestre, Armando J. D. Freire, Carmen S. R. |
Keywords: | Antifungal activity Bacterial nanocellulose Candida albicans Cutaneous treatment In-situpolymerization Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) |
Issue Date: | 1-Aug-2019 |
Publisher: | Elsevier |
Abstract: | The design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional network enabled the in-situ polymerization of the non-toxic and bioactive quaternary-ammonium monomer, which originated transparent nanocomposites containing 10 and 40 wt.% of cross-linked PMETAC. Furthermore, the nanocomposites exhibit UV-A and UV-B blocking properties, high water-uptake capacity, thermal stability up to 200 °C, good viscoelastic (storage modulus > 1.7 GPa) and mechanical (Young's modulus ≥2.4 GPa) properties and are non-cytotoxic to human keratinocytes (HaCaT cells). The fungal inactivation reached a 4.4 ± 0.14-log CFU reduction for the nanocomposite containing only 10 wt.% of cross-linked PMETAC. Hence, these bioactive and non-cytotoxic materials can constitute potentially effective systems for the treatment of C. albicans infections. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/37412 |
DOI: | 10.1016/j.carbpol.2019.04.046 |
ISSN: | 0144-8617 |
Appears in Collections: | CESAM - Artigos CICECO - Artigos DBio - Artigos DQ - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Nanocellulose-based antifungal nanocomposites againstthe polymorphic fungusCandida albicans.pdf | 1.05 MB | Adobe PDF | View/Open |
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