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Title: Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans
Author: Vilela, Carla
Oliveira, Helena
Almeida, Adelaide
Silvestre, Armando J. D.
Freire, Carmen S. R.
Keywords: Antifungal activity
Bacterial nanocellulose
Candida albicans
Cutaneous treatment
Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride)
Issue Date: 1-Aug-2019
Publisher: Elsevier
Abstract: The design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional network enabled the in-situ polymerization of the non-toxic and bioactive quaternary-ammonium monomer, which originated transparent nanocomposites containing 10 and 40 wt.% of cross-linked PMETAC. Furthermore, the nanocomposites exhibit UV-A and UV-B blocking properties, high water-uptake capacity, thermal stability up to 200 °C, good viscoelastic (storage modulus > 1.7 GPa) and mechanical (Young's modulus ≥2.4 GPa) properties and are non-cytotoxic to human keratinocytes (HaCaT cells). The fungal inactivation reached a 4.4 ± 0.14-log CFU reduction for the nanocomposite containing only 10 wt.% of cross-linked PMETAC. Hence, these bioactive and non-cytotoxic materials can constitute potentially effective systems for the treatment of C. albicans infections.
Peer review: yes
DOI: 10.1016/j.carbpol.2019.04.046
ISSN: 0144-8617
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