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http://hdl.handle.net/10773/37412
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DC Field | Value | Language |
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dc.contributor.author | Vilela, Carla | pt_PT |
dc.contributor.author | Oliveira, Helena | pt_PT |
dc.contributor.author | Almeida, Adelaide | pt_PT |
dc.contributor.author | Silvestre, Armando J. D. | pt_PT |
dc.contributor.author | Freire, Carmen S. R. | pt_PT |
dc.date.accessioned | 2023-04-27T13:28:57Z | - |
dc.date.available | 2023-04-27T13:28:57Z | - |
dc.date.issued | 2019-08-01 | - |
dc.identifier.issn | 0144-8617 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10773/37412 | - |
dc.description.abstract | The design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional network enabled the in-situ polymerization of the non-toxic and bioactive quaternary-ammonium monomer, which originated transparent nanocomposites containing 10 and 40 wt.% of cross-linked PMETAC. Furthermore, the nanocomposites exhibit UV-A and UV-B blocking properties, high water-uptake capacity, thermal stability up to 200 °C, good viscoelastic (storage modulus > 1.7 GPa) and mechanical (Young's modulus ≥2.4 GPa) properties and are non-cytotoxic to human keratinocytes (HaCaT cells). The fungal inactivation reached a 4.4 ± 0.14-log CFU reduction for the nanocomposite containing only 10 wt.% of cross-linked PMETAC. Hence, these bioactive and non-cytotoxic materials can constitute potentially effective systems for the treatment of C. albicans infections. | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FCTM%2F50011%2F2019/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAMB%2F50017%2F2019/PT | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00464%2F2017%2FCP1459%2FCT0033/PT | pt_PT |
dc.rights | openAccess | pt_PT |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
dc.subject | Antifungal activity | pt_PT |
dc.subject | Bacterial nanocellulose | pt_PT |
dc.subject | Candida albicans | pt_PT |
dc.subject | Cutaneous treatment | pt_PT |
dc.subject | In-situpolymerization | pt_PT |
dc.subject | Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) | pt_PT |
dc.title | Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans | pt_PT |
dc.type | article | pt_PT |
dc.description.version | published | pt_PT |
dc.peerreviewed | yes | pt_PT |
degois.publication.firstPage | 207 | pt_PT |
degois.publication.lastPage | 216 | pt_PT |
degois.publication.title | Carbohydrate polymers | pt_PT |
degois.publication.volume | 217 | pt_PT |
dc.identifier.doi | 10.1016/j.carbpol.2019.04.046 | pt_PT |
dc.identifier.essn | 1879-1344 | pt_PT |
Appears in Collections: | CESAM - Artigos CICECO - Artigos DBio - Artigos DQ - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Nanocellulose-based antifungal nanocomposites againstthe polymorphic fungusCandida albicans.pdf | 1.05 MB | Adobe PDF | View/Open |
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