Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10773/27684
Título: | Large scale comparative codon-pair context analysis unveils general rules that fine-tune evolution of mRNA primary structure |
Autor: | Moura, Gabriela Pinheiro, Miguel Arrais, Joel Gomes, Ana Cristina Carreto, Laura Freitas, Adelaide Oliveira, José L. Santos, Manuel A. S. |
Data: | 5-Set-2007 |
Editora: | Public Library of Science |
Resumo: | Background. Codon usage and codon-pair context are important gene primary structure features that influence mRNA decoding fidelity. In order to identify general rules that shape codon-pair context and minimize mRNA decoding error, we have carried out a large scale comparative codon-pair context analysis of 119 fully sequenced genomes. Methodologies/Principal Findings. We have developed mathematical and software tools for large scale comparative codon-pair context analysis. These methodologies unveiled general and species specific codon-pair context rules that govern evolution of mRNAs in the 3 domains of life. We show that evolution of bacterial and archeal mRNA primary structure is mainly dependent on constraints imposed by the translational machinery, while in eukaryotes DNA methylation and tri-nucleotide repeats impose strong biases on codon-pair context. Conclusions. The data highlight fundamental differences between prokaryotic and eukaryotic mRNA decoding rules, which are partially independent of codon usage. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/27684 |
DOI: | 10.1371/journal.pone.0000847 |
Aparece nas coleções: | CESAM - Artigos DBio - Artigos DMat - Artigos IEETA - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Moura et al. 2007b.pdf | 491.19 kB | Adobe PDF | Ver/Abrir |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.