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http://hdl.handle.net/10773/25586
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DC Field | Value | Language |
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dc.contributor.author | Gomes, Maria C. | pt_PT |
dc.contributor.author | Woranovicz-Barreira, Sandra M. | pt_PT |
dc.contributor.author | Faustino, Maria A. F. | pt_PT |
dc.contributor.author | Fernandes, Rosa | pt_PT |
dc.contributor.author | Neves, Maria G. P. M. S. | pt_PT |
dc.contributor.author | Tomé, Augusto C. | pt_PT |
dc.contributor.author | Gomes, Newton C. M. | pt_PT |
dc.contributor.author | Almeida, Adelaide | pt_PT |
dc.contributor.author | Cavaleiro, José A. S. | pt_PT |
dc.contributor.author | Cunha, Ângela | pt_PT |
dc.contributor.author | Tomé, João P. C. | pt_PT |
dc.date.accessioned | 2019-03-14T11:42:20Z | - |
dc.date.available | 2019-03-14T11:42:20Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1474-905X | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10773/25586 | - |
dc.description.abstract | This work reports the photophysical and biological evaluation of five cationic porphyrins as photosensitizers (PS) for the photodynamic inactivation (PDI) of Penicillium chrysogenum conidia. Two different cationic porphyrin groups were synthesized from 5,10,15,20-tetrakis(4-pyridyl)porphyrin and 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin. The photostability and singlet oxygen generation studies showed that these molecules are photostable and efficient singlet oxygen generators. PDI experiments of P. chrysogenum conidia conducted with 50 mmol L-1 of photosensitiser under white light at a fluence rate of 200 mW cm-2 over 20 min showed that the most effective PS caused a 4.1 log reduction in the concentration of viable conidia. The present results show that porphyrins 1a and 1b are more efficient PSs than porphyrin 2a while porphyrins 1c and 2b show no inactivation of P. chrysogenum. It is also clear that the effectiveness of the molecule as PS for antifungal PDI is strongly related with the porphyrin substituent groups, and consequently their solubility in physiological media. The average amount of PS adsorbed per viable conidium was a determining factor in the photoinactivation efficiency and varied between the different studied PSs. Cationic PSs 1a and 1b might be promising anti-fungal PDI agents with potential applications in phytosanitation, biofilm control, bioremediation, and wastewater treatment. | pt_PT |
dc.description.sponsorship | Thanks are due to the Portuguese Foundation for Science and Technology (FCT) and FEDER, for funding the QOPNA and CESAM research groups, and the Portuguese National NMR Network. This work had financial support from project PTDC/QUI/65228/2006. M. C. Gomes was financed by the BI grant (BI/UI55/4856/2010) and S. M. Woranovicz-Barreira is thankful to Federal University of Paraná, Brazil, for her leave of absence. The authors are also grateful to Prof. Charles Drain for helpful discussions, and to Dr Artur Alves for the molecular confirmation of the identification of the fungal strain. | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | Royal Society of Chemistry | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/65228/PT | pt_PT |
dc.rights | restrictedAccess | pt_PT |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.title | Photodynamic inactivation of Penicillium chrysogenum conidia by cationic porphyrins | pt_PT |
dc.type | article | pt_PT |
dc.description.version | published | pt_PT |
dc.peerreviewed | yes | pt_PT |
degois.publication.firstPage | 1735 | pt_PT |
degois.publication.lastPage | 1743 | pt_PT |
degois.publication.title | Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences | pt_PT |
degois.publication.volume | 10 | pt_PT |
dc.identifier.doi | 10.1039/c1pp05174a | pt_PT |
dc.identifier.essn | 1474-9092 | pt_PT |
Appears in Collections: | CESAM - Artigos DBio - Artigos DQ - Artigos QOPNA - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Gomes et al. - 2011 - Photodynamic inactivation of Penicillium chrysogen.pdf | 1.35 MB | Adobe PDF |
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