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Title: Differential gene expression in Iberian green frogs (Pelophylax perezi) inhabiting a deactivated uranium mine
Author: Marques, Sérgio M.
Chaves, Sandra
Gonçalves, Fernando
Pereira, Ruth
Keywords: Differential gene expression
Iberian green frogs
Pelophylax perezi
Uranium mine
Issue Date: 2013
Publisher: Elsevier
Abstract: Iberian green frogs (Pelophylax perezi) were found inhabiting a deactivated uranium mine, especially an effluent pond, seriously contaminated with metals and radionuclides. These animals were previously assessed for oxidative stress parameters and did not revealed significant alterations. In order to better understand which mechanisms may be involved in the ability to withstand permanent contamination gene expression analysis was performed in the liver, through suppression subtractive hybridization (SSH). The SSH outcome in the liver revealed the up-regulation of genes coding for the ribosomal protein L7a and for several proteins typical from blood plasma: fibrinogen, hemoglobin and albumin. Besides their normal function, some of these proteins can play an important role as protective agents against oxidative stress. This work provides new insights on possible basal protection mechanisms that may act in organisms exposed chronically to contamination.
Peer review: yes
DOI: 10.1016/j.ecoenv.2012.10.010
ISSN: 0147-6513
Appears in Collections:CESAM - Artigos
DBio - Artigos

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