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Title: Coral aquaculture to support drug discovery
Author: Leal, Miguel C.
Calado, Ricardo
Sheridan, Christopher
Alimonti, Andrea
Osinga, Ronald
Keywords: Bioactive compounds
Biomass supply
Economic feasibility
Issue Date: 2013
Publisher: Elsevier
Abstract: Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolites. The ex hospite culture of coral symbiotic microbiota is extremely challenging and only limited examples of successful culture exist today. By contrast, in toto aquaculture of corals is a commonly applied technology to produce corals for aquaria. Here, we suggest that coral aquaculture could as well be a viable and economically feasible option to produce the biomass required to execute the first steps of the NP-based drug discovery pipeline.
Peer review: yes
DOI: 10.1016/j.tibtech.2013.06.004
ISSN: 0167-7799
Appears in Collections:CESAM - Artigos
DBio - Artigos

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