Physiological collagen architecture in engineered tissue cartilage through a combined approach of mechanical stimulus and anisotropic fibrous scaffolds

Abstract

This work consists on improvement of the functionality of tissue engineered cartilage through a combined approach of mechanical stimulus with anisotropic fibrous scaffolds provided on a bioreactor culture environment, in order to bring the structural organization of engineered cartilage close to the native tissue, reducing the risk of failure of this promising method for osteoarthritis treatment.