Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/40040
Title: | Gal-3 Protein Expression and Localization in Prostate Tumours |
Author: | Lima, Tânia Macedo-Silva, Catarina Felizardo, Diana Fraga, João Carneiro, Isa Jerónimo, Carmen Henrique, Rui Fardilha, Margarida Vitorino, Rui |
Issue Date: | Mar-2023 |
Publisher: | MDPI |
Abstract: | Gal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising diagnostic role of Gal-3 in the urine of PCa patients found in our previous study, its concordant gene and protein expression levels, and its involvement in PCa-related biological processes (e.g., morphogenesis of the prostate gland epithelium), we aimed to investigate this protein immunohistochemically in tumour and normal prostate tissues. Gal-3 protein expression was evaluated in 48 tumour prostate tissues, eight normal prostate tissues and 14 adjacent-normal prostate tissues. Decreased Gal-3 staining was detected in tumour tissues compared with normal tissues. Although Gal-3 staining was decreased in tumour tissues with GS 5-8 and pT2 and pT3 stages compared with normal prostate tissue, no correlation was found between Gal-3 expression and PCa progression. In the present study, the pattern of cellular localization differed between groups, as Gal-3 was predominantly excluded from the nucleus in tumour tissues. Furthermore, Gal-3 had no significant effect on survival and relapse in these PCa patients. This work confirms Gal-3 as a promising marker for PCa diagnosis. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/40040 |
DOI: | 10.3390/curroncol30030206 |
ISSN: | 1718-7729 |
Appears in Collections: | IBIMED - Artigos DQ - Artigos DCM - Artigos REQUIMTE - Artigos |
Files in This Item:
File | Description | Size | Format | |
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curroncol-30-00206 (1).pdf | 3.52 MB | Adobe PDF | View/Open |
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