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http://hdl.handle.net/10773/37705
Title: | Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives |
Author: | Khatir-Hamdi, Nejla Makhloufi-Chebli, Malika Silva, Artur M. S. Brahimi, Méziane Grib, Hocine |
Keywords: | Coumarin Electrophilic substitution Theoretical calculation Cold-iodination Radioiodination Ecofriendly strategy |
Issue Date: | Sep-2019 |
Publisher: | Elsevier |
Abstract: | Combination of the calculation of reactivity descriptors and the cold iodine test for some coumarin derivatives was used in order to optimize the radioiodination reaction. The strongly nucleophilic predicted coumarins were subjected to the action of cold iodine. With two coumarins substituted at 3 by the 2-hydroxybenzoyl group, iodination did not occur but a product of intramolecular heterocyclization was obtained. This strategy is useful for economic and environmentally friendly radioiodination. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/37705 |
DOI: | 10.1016/j.apradiso.2019.06.024 |
ISSN: | 0969-8043 |
Appears in Collections: | DQ - Artigos QOPNA - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Proposal for an ecofriendly and economic strategy for efficient radioiodination of.pdf | 490.59 kB | Adobe PDF | View/Open | |
Proposal for an ecofriendly and economic strategy for efficient radioiodination of.pdf | 490.59 kB | Adobe PDF |
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