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Title: Primary versus secondary source of data in observational studies and heterogeneity in meta-analyses of drug effects: a survey of major medical journals
Author: Prada-Ramallal, Guillermo
Roque, Fátima
Herdeiro, Maria Teresa
Takkouche, Bahi
Figueiras, Adolfo
Keywords: Drug
Observational studies
Source of data
Issue Date: Sep-2018
Publisher: BMC
Abstract: The data from individual observational studies included in meta-analyses of drug effects are collected either from ad hoc methods (i.e. "primary data") or databases that were established for non-research purposes (i.e. "secondary data"). The use of secondary sources may be prone to measurement bias and confounding due to over-the-counter and out-of-pocket drug consumption, or non-adherence to treatment. In fact, it has been noted that failing to consider the origin of the data as a potential cause of heterogeneity may change the conclusions of a meta-analysis. We aimed to assess to what extent the origin of data is explored as a source of heterogeneity in meta-analyses of observational studies.
Peer review: yes
DOI: 10.1186/s12874-018-0561-3
ISSN: 1471-2288
Appears in Collections:IBIMED - Artigos
DCM - Artigos

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