Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/31044
Title: | Primary versus secondary source of data in observational studies and heterogeneity in meta-analyses of drug effects: a survey of major medical journals |
Author: | Prada-Ramallal, Guillermo Roque, Fátima Herdeiro, Maria Teresa Takkouche, Bahi Figueiras, Adolfo |
Keywords: | Drug Heterogeneity Meta-analysis Observational studies Out-of-pocket Over-the-counter Source of data |
Issue Date: | Sep-2018 |
Publisher: | BMC |
Abstract: | The data from individual observational studies included in meta-analyses of drug effects are collected either from ad hoc methods (i.e. "primary data") or databases that were established for non-research purposes (i.e. "secondary data"). The use of secondary sources may be prone to measurement bias and confounding due to over-the-counter and out-of-pocket drug consumption, or non-adherence to treatment. In fact, it has been noted that failing to consider the origin of the data as a potential cause of heterogeneity may change the conclusions of a meta-analysis. We aimed to assess to what extent the origin of data is explored as a source of heterogeneity in meta-analyses of observational studies. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/31044 |
DOI: | 10.1186/s12874-018-0561-3 |
ISSN: | 1471-2288 |
Appears in Collections: | IBIMED - Artigos DCM - Artigos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
artigo.pdf | 684.52 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.