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Title: Spectroscopic features of cancer cells: FTIR spectroscopy as a tool for early diagnosis
Author: Santos, Francisco
Magalhães, Sandra
Henriques, Magda Carvalho
Fardilha, Margarida
Nunes, Alexandra
Keywords: Cancer
Metabolic profile
FTIR spectroscopy
Cell lines
Multivariate analysis
Issue Date: 2018
Publisher: Bentham Science Publishers
Abstract: Globally, cancer is one of the leading causes of death, so the development of strategies for an early diagnosis of cancer is of great importance. Biochemical alterations precede morphological changes in cells and tissues, so studying cancer metabolome seems like a reasonable approach for early diagnosis, prognosis and to follow treatment progression. Fourier-transform infrared (FTIR) spectroscopy is a valuable tool for studying the metabolome of biological samples, such as cancer cell lines. Unlike staining procedures and other histopathologic approaches, this technique is rapid, non-destructive and does not require reagents. The spectral differences that result from probing the biochemical composition of cancer and normal cells are indicative of distinct metabolic profiles, which allows the discrimination of different cells. Using FTIR spectroscopy and multivariate statistical analysis, several alterations concerning the content of lipids, proteins, nucleic acids and carbohydrates have been identified in cancer cells, some of which can be regarded as potential biomarkers. This review focuses on FTIR spectroscopy as a metabolomics tool to study and characterize cancer cell lines.
Peer review: yes
DOI: 10.2174/2213235X06666180521084551
ISSN: 2213-235X
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DCM - Artigos

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