Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/29539
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSantos, Franciscopt_PT
dc.contributor.authorMagalhães, Sandrapt_PT
dc.contributor.authorHenriques, Magda Carvalhopt_PT
dc.contributor.authorFardilha, Margaridapt_PT
dc.contributor.authorNunes, Alexandrapt_PT
dc.date.accessioned2020-10-21T16:53:32Z-
dc.date.available2020-10-21T16:53:32Z-
dc.date.issued2018-
dc.identifier.issn2213-235Xpt_PT
dc.identifier.urihttp://hdl.handle.net/10773/29539-
dc.description.abstractGlobally, cancer is one of the leading causes of death, so the development of strategies for an early diagnosis of cancer is of great importance. Biochemical alterations precede morphological changes in cells and tissues, so studying cancer metabolome seems like a reasonable approach for early diagnosis, prognosis and to follow treatment progression. Fourier-transform infrared (FTIR) spectroscopy is a valuable tool for studying the metabolome of biological samples, such as cancer cell lines. Unlike staining procedures and other histopathologic approaches, this technique is rapid, non-destructive and does not require reagents. The spectral differences that result from probing the biochemical composition of cancer and normal cells are indicative of distinct metabolic profiles, which allows the discrimination of different cells. Using FTIR spectroscopy and multivariate statistical analysis, several alterations concerning the content of lipids, proteins, nucleic acids and carbohydrates have been identified in cancer cells, some of which can be regarded as potential biomarkers. This review focuses on FTIR spectroscopy as a metabolomics tool to study and characterize cancer cell lines.pt_PT
dc.language.isoengpt_PT
dc.publisherBentham Science Publisherspt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjectMetabolomicspt_PT
dc.subjectMetabolic profilept_PT
dc.subjectFTIR spectroscopypt_PT
dc.subjectCell linespt_PT
dc.subjectMultivariate analysispt_PT
dc.titleSpectroscopic features of cancer cells: FTIR spectroscopy as a tool for early diagnosispt_PT
dc.typearticlept_PT
dc.description.versionpublishedpt_PT
dc.peerreviewedyespt_PT
degois.publication.firstPage103pt_PT
degois.publication.issue2pt_PT
degois.publication.lastPage111pt_PT
degois.publication.titleCurrent Metabolomicspt_PT
degois.publication.volume6pt_PT
dc.identifier.doi10.2174/2213235X06666180521084551pt_PT
dc.identifier.essn2213-2368pt_PT
Appears in Collections:IBIMED - Artigos
DCM - Artigos

Files in This Item:
File Description SizeFormat 
Spectroscopic features of cancer cells FTIR spectroscopy as a tool for early diagnosis.pdf326.44 kBAdobe PDFView/Open


FacebookTwitterLinkedIn
Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.