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Title: Computational and statistical methodologies for ORFeome primary structure analysis
Author: Moura, Gabriela
Pinheiro, Miguel
Freitas, Adelaide Valente
Oliveira, José Luís
Santos, Manuel A. S.
Keywords: Genome
Gene primary structure
Codon context
Codon usage
Issue Date: 2007
Publisher: Humana Press
Abstract: Codon usage and context are biased in open reading frames (ORFs) of most genomes. Codon usage is largely influenced by biased genome G+C pressure, in particular in prokaryotes, but the general rules that govern the evolution of codon context remain largely elusive. In order to shed new light into this question we have developed computational, statistical and graphical tools for analysis of codon context on an ORFeome wide scale. In here, we describe these methodologies in detail and show how they can be used for analysis of ORFs of any genome sequenced.
Peer review: yes
ISBN: 978-1-58829-693-1
Appears in Collections:CESAM - Capítulo de livro
DETI - Artigos
DBio - Artigos
DMat - Artigos
IEETA - Artigos

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