Please use this identifier to cite or link to this item:
Title: Cancer syndromes and therapy by stop-codon readthrough
Author: Bordeira-Carriço, Renata
Pêgo, Ana Paula
Santos, Manuel
Oliveira, Carla
Keywords: Aminoglycosides
Hereditary cancer syndromes
Nonsense-mediated decay (NMD)
Premature termination codon (PTC)
Issue Date: Nov-2012
Publisher: Elsevier
Abstract: Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising results for treating patients with cystic fibrosis and Duchenne muscular dystrophy. Transgenic expression of suppressor-tRNAs and depleting translation termination factors are, among others, potential strategies for treating PTC-associated diseases. In this review, the potential of using readthrough strategies as a therapy for cancer syndromes is discussed, and we consider the effect of nonsense-mediated decay and other factors on readthrough efficiency.
Peer review: yes
DOI: 10.1016/j.molmed.2012.09.004
ISSN: 1471-4914
Appears in Collections:CESAM - Artigos
DBio - Artigos

Files in This Item:
File Description SizeFormat 
Bordeira-Carrico et al. - 2012 - Cancer syndromes and therapy by stop-codon readthr.pdf481.74 kBAdobe PDFrestrictedAccess

Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.