Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10773/26583
Título: | Cancer syndromes and therapy by stop-codon readthrough |
Autor: | Bordeira-Carriço, Renata Pêgo, Ana Paula Santos, Manuel Oliveira, Carla |
Palavras-chave: | Aminoglycosides Hereditary cancer syndromes Nonsense-suppression PTC124 Readthrough Suppressor-tRNA Nonsense-mediated decay (NMD) Premature termination codon (PTC) |
Data: | Nov-2012 |
Editora: | Elsevier |
Resumo: | Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising results for treating patients with cystic fibrosis and Duchenne muscular dystrophy. Transgenic expression of suppressor-tRNAs and depleting translation termination factors are, among others, potential strategies for treating PTC-associated diseases. In this review, the potential of using readthrough strategies as a therapy for cancer syndromes is discussed, and we consider the effect of nonsense-mediated decay and other factors on readthrough efficiency. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/26583 |
DOI: | 10.1016/j.molmed.2012.09.004 |
ISSN: | 1471-4914 |
Aparece nas coleções: | CESAM - Artigos DBio - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Bordeira-Carrico et al. - 2012 - Cancer syndromes and therapy by stop-codon readthr.pdf | 481.74 kB | Adobe PDF |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.