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Title: Biochemical and metabolic effects of a short-term exposure to nanoparticles of titanium silicate in tadpoles of Pelophylax perezi (Seoane)
Author: Salvaterra, T.
Alves, M. G.
Domingues, I.
Pereira, R.
Rasteiro, M. G.
Carvalho, R. A.
Soares, A. M. V. M.
Lopes, I.
Keywords: 1H NMR analysis
Oxidative stress
Pelophylax perezi
Issue Date: 2013
Publisher: Elsevier
Abstract: This study aimed to evaluate sublethal effects of a short-term exposure (96h) to titanium silicate nanoparticles (TiSiO4-NP) on Pelophylax perezi tadpoles. Tadpoles were exposed to five concentrations of TiSiO4-NP (8.2, 10.2, 12.8, 16 and 20mg/L) plus a control. Effect criteria were: mortality, cholinesterases, glutathione S-transferases, lactate dehydrogenase, and catalase activities, and alanine and lactate contents. Light scattering was used for physical characterization of TiSiO4-NP suspensions, revealing a high aggregation state of the NP, consistent with low z-potential values (<30mV). Mortality among TiSiO4-NP treatments was <11%. Significant differences relatively to the control were observed at the biochemical level (for CAT and LDH) and in lactate and alanine contents, which may end-up in increased oxidative stress. Overall, some of the monitored endpoints suggest metabolic alterations in TiSiO4-NP exposed tadpoles, highlighting the potential of TiSiO4-NP long-term effects on these organisms.
Peer review: yes
DOI: 10.1016/j.aquatox.2012.12.014
ISSN: 0166-445X
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