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|Title:||Biochemical and metabolic effects of a short-term exposure to nanoparticles of titanium silicate in tadpoles of Pelophylax perezi (Seoane)|
Alves, M. G.
Rasteiro, M. G.
Carvalho, R. A.
Soares, A. M. V. M.
|Keywords:||1H NMR analysis|
|Abstract:||This study aimed to evaluate sublethal effects of a short-term exposure (96h) to titanium silicate nanoparticles (TiSiO4-NP) on Pelophylax perezi tadpoles. Tadpoles were exposed to five concentrations of TiSiO4-NP (8.2, 10.2, 12.8, 16 and 20mg/L) plus a control. Effect criteria were: mortality, cholinesterases, glutathione S-transferases, lactate dehydrogenase, and catalase activities, and alanine and lactate contents. Light scattering was used for physical characterization of TiSiO4-NP suspensions, revealing a high aggregation state of the NP, consistent with low z-potential values (<30mV). Mortality among TiSiO4-NP treatments was <11%. Significant differences relatively to the control were observed at the biochemical level (for CAT and LDH) and in lactate and alanine contents, which may end-up in increased oxidative stress. Overall, some of the monitored endpoints suggest metabolic alterations in TiSiO4-NP exposed tadpoles, highlighting the potential of TiSiO4-NP long-term effects on these organisms.|
|Appears in Collections:||CESAM - Artigos|
DBio - Artigos
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|Salvaterra et al. - 2013 - Biochemical and metabolic effects of a short-term .pdf||204.33 kB||Adobe PDF|
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