Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10773/20168
Título: | Smart electroconductive bioactive ceramics to promote in situ electrostimulation of bone |
Autor: | Mata, Diogo Oliveira, Filipe J. Neto, Miguel A. Belmonte, Manuel Bastos, Alexandre C. Lopes, Maria A. Gomes, Pedro S. Fernandes, Maria H. Silva, Rui F. |
Palavras-chave: | MESENCHYMAL STEM-CELLS PULSED ELECTROMAGNETIC-FIELDS CARBON NANOTUBES OSTEOGENIC DIFFERENTIATION ELECTRICAL-STIMULATION CALCIUM-CHANNELS VIBRATING PROBE DRUG-DELIVERY CURRENTS VITRO |
Data: | 2015 |
Editora: | ROYAL SOC CHEMISTRY |
Resumo: | Biomaterials can still be reinvented to become simple and universal bone regeneration solutions. Following this roadmap, conductive CNT-based \"smart\" materials accumulate exciting grafting qualities for tuning the in vitro cellular phenotype. Biphasic electrical stimulation of human osteoblastic cells was performed in vitro on either dielectric bioactive bone grafts or conductive CNT-reinforced composites. The efficiency of the electrical stimuli delivery, as well as the effect of stimulation on cellular functions were investigated. Conductive substrates boosted the local culture medium conductivity and the confinement of the exogenous electrical fields. Hence, bone cell proliferation, DNA content and mRNA expression were maximized on the conductive substrates yielding superior stimuli delivering efficiency over dielectric ones. These findings are suggestive that bioactive bone grafts with electrical conductivity are capable of high spatial and temporal control of bone cell stimulation. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/20168 |
DOI: | 10.1039/c4tb01628a |
ISSN: | 2050-750X |
Versão do Editor: | 10.1039/c4tb01628a |
Aparece nas coleções: | CICECO - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Smart electroconductive bioactive ceramics to promote in situ electrostimulation of bone_10.1039c4tb01628a.pdf | 11.08 MB | Adobe PDF |
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