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Title: Inverted methoxypyridinium phthalocyanines for PDI of pathogenic bacteria
Author: Lourenço, Leandro M. O.
Sousa, Andreina
Gomes, Maria C.
Faustino, Maria A. F.
Almeida, Adelaide
Silva, Artur M. S.
Neves, Maria G. P. M. S.
Cavaleiro, José A. S.
Cunha, Ângela
Tomé, João P. C.
Issue Date: 2015
Publisher: Royal Society of Chemistry
Abstract: Phthalocyanines (Pc) are photoactive molecules that can absorb and emit light in a large range of the UV-Vis spectrum with recognized potential for medical applications. Considering the biomedical applications an important limitation of these compounds is their low solubility in water. The use of suitable pyridinium groups on Pc is a good strategy to solve this drawback and to make them more effective to photoinactivate Gram-negative bacteria via a photodynamic inactivation (PDI) approach. Herein, an easy synthetic access to obtain inverted tetra- and octa-methoxypyridinium phthalocyanines (compounds 5 and 6) and also their efficiency to photoinactivate a recombinant bioluminescent strain of Escherichia coli is described. The obtained results were compared with the ones obtained when more conventional thiopyridinium phthalocyanines (compounds 7 and 8) were used. This innovative study comparing thiopyridinium and inverted methoxypyridinium moieties on cationic Pc is reported for the first time taking into account the efficiency of singlet oxygen (1O2) generation, water solubility and uptake properties.
Peer review: yes
DOI: 10.1039/c5pp00145e
ISSN: 1474-905X
Appears in Collections:CESAM - Artigos
DBio - Artigos
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