Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/9578
Title: | Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitosan scaffolds for skin regeneration |
Author: | Veleirinho, B. Coelho, D.S. Dias, P.F. Maraschin, M. Ribeiro-do-Valle, R.M. Lopes da Silva, J.A. |
Keywords: | PHBV chitosan electrospinning scaffold skin healing |
Issue Date: | Nov-2012 |
Publisher: | Elsevier |
Abstract: | The purpose of this study was to evaluate hybrid poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitosan nanofibrous mats as scaffolds for skin engineering. In vitro studies were carried out to test the potential of the scaffolds for fibroblasts adhesion, viability, and proliferation (L929 cell line). The in vivo performance was also studied in a full-thickness wound healing model. PHBV/chitosan 4:1 w/w exhibited a higher in vitro biocompatibility and a better ability for cell adhesion and growth, compared to PHBV/chitosan 2:3 w/w. The in vivo assay also revealed the better performance of this scaffold, improving the wound healing process in rats. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/9578 |
DOI: | 10.1016/j.ijbiomac.2012.05.023 |
ISSN: | 0141-8130 |
Appears in Collections: | DQ - Artigos |
Files in This Item:
File | Description | Size | Format | |
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veleirinho_IJBM2012.pdf | Documento principal | 2.06 MB | Adobe PDF |
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