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Title: History of exposure to copper influences transgenerational gene expression responses in Daphnia magna
Author: Jeremias, Guilherme
Muñiz-González, , Ana-Belén
Mendes Gonçalves, Fernando José
Martínez-Guitarte, José-Luis
Asselman, Jana
Luísa Pereira, Joana
Keywords: Metals
Molecular responses
Transgenerational effects
Issue Date: 2024
Publisher: Taylor & Francis
Abstract: The establishment of transgenerational effects following chemical exposure is a powerful phenomenon, capable of modulating ecosystem health beyond exposure periods. This study assessed the transgenerational effects occurring due to copper exposure in the invertebrate D. magna at the transcriptional level, while evaluating the role of exposure history on such responses. Thus, daphnids acclimated for several generations in a copper vs. clean medium were then exposed for one generation (F0) to this metal, and monitored for the following non-exposed generations (F1, F2 and F3). Organisms differing in exposure histories showed remarkably different transcriptional profiles at the F0, with naïve organisms being more profoundly affected. These trends were confirmed for F3 treatments, which presented different transcriptional patterns for genes involved in detoxification, oxidative stress, DNA damage repair, circadian clock functioning and epigenetic regulation. Furthermore, regardless of exposure history, a great number of histone modifier genes were always found transcriptionally altered, thus suggesting the involvement of histone modifications in the response of Daphnia to metal exposure. Lastly, remarkably distinct transgenerational transcriptional responses were found between naïve and non-naïve organisms, thereby highlighting the influence of exposure history on gene expression and confirming the capacity of metals to determine transgenerational transcriptional effects across non-exposed generations.
Peer review: yes
DOI: 10.1080/15592294.2023.2296275
ISSN: 1559-2294
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Appears in Collections:CESAM - Artigos
DBio - Artigos

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