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Title: Outcome measures frequently used to assess muscle strength in patients with myotonic dystrophy type 1: a systematic review
Author: Mateus, Tiago
Costa, Adriana
Viegas, Diana
Marques, Alda
Herdeiro, Maria Teresa
Rebelo, Sandra
Keywords: Myotonic dystrophy type 1
Cardiac muscle strength
Skeletal muscle strength
Respiratory muscle strength
Issue Date: Feb-2022
Publisher: Elsevier
Abstract: Measurement of muscle strength is fundamental for the management of patients with myotonic dystrophy type 1 (DM1). Nevertheless, guidance on this topic is somewhat limited due to heterogeneous outcome measures used. This systematic literature review aimed to summarize the most frequent outcome measures to assess muscle strength in patients with DM1. We searched on Pubmed, Web of Science and Embase databases. Observational studies using measures of muscle strength assessment in adult patients with DM1 were included. From a total of 80 included studies, 24 measured cardiac, 45 skeletal and 23 respiratory muscle strength. The most common method and outcome measures used to assess cardiac muscle strength were echocardiography and ejection fraction, for skeletal muscle strength were quantitative muscle test, manual muscle test and maximum isometric torque and medical research council and for respiratory muscle strength were manometry and maximal inspiratory and expiratory pressure. We successfully gathered the more consensual methods and measures to evaluate muscle strength in future clinical studies, particularly to test muscle strength response to treatments in patients with DM1. Future consensus on a set of measures to evaluate muscle strength (core outcome set), is important for these patients.
Peer review: yes
DOI: 10.1016/j.nmd.2021.09.014
ISSN: 0960-8966
Appears in Collections:IBIMED - Artigos
ESSUA - Artigos
DCM - Artigos
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