Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/33266
Title: Solvatochromism as a new tool to distinguish structurally similar compounds
Author: Madeira, Pedro P.
Loureiro, Joana A.
Freire, Mara G.
Coutinho, João A. P.
Keywords: Solvatochromic method
Structurally similar compounds
Biosimilars
Quality control
Biomedical diagnosis
Issue Date: 15-Jan-2019
Publisher: Elsevier
Abstract: It is here reported a new concept based on solvatochromism to distinguish structurally similar compounds in aqueous solutions by the analysis of the stabilization of electronic excited states. The sensitivity of this approach to differentiate similar organic compounds, such as structural isomers or compound differing in the number of methylene groups, or proteins with conformational changes induced by being or not bound to cofactors, differing in two amino acids substitutions, or differing in their glycosylation profile, is demonstrated. The sensitivity of the proposed approach, based on the solvatochromic method, opens the path to its use as an auxiliary analytical tool in biomedical diagnosis/prognosis or in quality control of biologic-based drugs.
Peer review: yes
URI: http://hdl.handle.net/10773/33266
DOI: 10.1016/j.molliq.2018.11.050
ISSN: 0167-7322
Appears in Collections:CICECO - Artigos
DQ - Artigos

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