Please use this identifier to cite or link to this item:
http://hdl.handle.net/10773/28625
Title: | Low Complexity Regions behave as tRNA sponges to help co-translational folding of plasmodial proteins |
Author: | Frugier, Magali Bour, Tania Ayach, Maya Santos, Manuel A. S. Rudinger-Thirion, Joëlle Théobald-Dietrich, Anne Pizzi, Elizabetta |
Keywords: | Low complexity regions Plasmodium falciparum Co‐translational folding |
Issue Date: | 21-Jan-2010 |
Publisher: | Elsevier |
Abstract: | In most organisms, the information necessary to specify the native 3D-structures of proteins is encoded in the corresponding mRNA sequences. Translational accuracy and efficiency are coupled and sequences that are slowly translated play an essential role in the concomitant folding of protein domains. Here, we suggest that the well-known mechanisms for the regulation of translational efficiency, which involves mRNA structure and/or asymmetric tRNA abundance, do not apply to all organisms. We propose that Plasmodium, the parasite responsible for malaria, uses an alternative strategy to slow down ribosomal speed and avoid multidomain protein misfolding during translation. In our model, the abundant Low Complexity Regions present in Plasmodium proteins replace the codon preferences, which influence the assembly of protein secondary structures. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/28625 |
DOI: | 10.1016/j.febslet.2009.11.004 |
ISSN: | 0014-5793 |
Appears in Collections: | CESAM - Artigos DBio - Artigos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Frugier et al. - 2010 - Low Complexity Regions behave as tRNA sponges to h.pdf | 2.17 MB | Adobe PDF | ![]() |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.