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Title: tRNA deregulation and its consequences in cancer
Author: Santos, Mafalda
Fidalgo, Ana
Varanda, A. Sofia
Oliveira, Carla
Santos, Manuel A. S.
Keywords: tRNAs
Protein synthesis errors
Codon usage
Drug resistance
Issue Date: Oct-2019
Publisher: Elsevier
Abstract: The expression of transfer RNAs (tRNAs) is deregulated in cancer cells but the mechanisms and functional meaning of such deregulation are poorly understood. The proteome of cancer cells is not fully encoded by their transcriptome, however, the contribution of mRNA translation to such diversity remains to be elucidated. We review data supporting the hypothesis that tRNA expression deregulation and translational error rate is an important contributor to proteome diversity and cell population heterogeneity, genome instability, and drug resistance in tumors. This hypothesis is aligned with recent data in various model organisms, showing unanticipated adaptive roles of translational errors (adaptive mistranslation), expression control of specific gene subsets by tRNAs, and proteome diversification by elevation of translational error rates in tumors.
Peer review: yes
DOI: 10.1016/j.molmed.2019.05.011
ISSN: 1471-4914
Appears in Collections:IBIMED - Artigos
DCM - Artigos

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