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http://hdl.handle.net/10773/27749
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DC Field | Value | Language |
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dc.contributor.author | Santos, Mafalda | pt_PT |
dc.contributor.author | Fidalgo, Ana | pt_PT |
dc.contributor.author | Varanda, A. Sofia | pt_PT |
dc.contributor.author | Oliveira, Carla | pt_PT |
dc.contributor.author | Santos, Manuel A. S. | pt_PT |
dc.date.accessioned | 2020-03-02T17:41:49Z | - |
dc.date.available | 2020-03-02T17:41:49Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1471-4914 | pt_PT |
dc.identifier.uri | http://hdl.handle.net/10773/27749 | - |
dc.description.abstract | The expression of transfer RNAs (tRNAs) is deregulated in cancer cells but the mechanisms and functional meaning of such deregulation are poorly understood. The proteome of cancer cells is not fully encoded by their transcriptome, however, the contribution of mRNA translation to such diversity remains to be elucidated. We review data supporting the hypothesis that tRNA expression deregulation and translational error rate is an important contributor to proteome diversity and cell population heterogeneity, genome instability, and drug resistance in tumors. This hypothesis is aligned with recent data in various model organisms, showing unanticipated adaptive roles of translational errors (adaptive mistranslation), expression control of specific gene subsets by tRNAs, and proteome diversification by elevation of translational error rates in tumors. | pt_PT |
dc.language.iso | eng | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.relation | POCI-01-0145-FEDER-007274 | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/132983/PT | pt_PT |
dc.relation | NORTE-01-0145-FEDER-000029 | pt_PT |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147343/PT | pt_PT |
dc.relation | PTDC/MED-ONC/28834/2017 | pt_PT |
dc.relation | PTDC/BIA-MIB/31238/2017 | pt_PT |
dc.relation | CENTRO-01-0145-FEDER-000003 | pt_PT |
dc.rights | restrictedAccess | pt_PT |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
dc.subject | tRNAs | pt_PT |
dc.subject | Protein synthesis errors | pt_PT |
dc.subject | Codon usage | pt_PT |
dc.subject | Cancer | pt_PT |
dc.subject | Drug resistance | pt_PT |
dc.title | tRNA deregulation and its consequences in cancer | pt_PT |
dc.type | article | pt_PT |
dc.description.version | published | pt_PT |
dc.peerreviewed | yes | pt_PT |
degois.publication.firstPage | 853 | pt_PT |
degois.publication.issue | 10 | pt_PT |
degois.publication.lastPage | 865 | pt_PT |
degois.publication.title | Trends in Molecular Medicine | pt_PT |
degois.publication.volume | 25 | pt_PT |
dc.identifier.doi | 10.1016/j.molmed.2019.05.011 | pt_PT |
dc.identifier.essn | 1471-499X | pt_PT |
Appears in Collections: | IBIMED - Artigos DCM - Artigos |
Files in This Item:
File | Description | Size | Format | |
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tRNA Deregulation and Its Consequences in Cancer _ Elsevier Enhanced Reader.pdf | 7.97 MB | Adobe PDF |
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