Please use this identifier to cite or link to this item:
Title: Driving change: the evolution of alternative genetic codes
Author: Santos, Manuel A. S.
Moura, Gabriela
Massey, Steven E.
Tuite, Mick F.
Issue Date: Feb-2004
Publisher: Elsevier
Abstract: Pioneering studies in the 1960s that elucidated the genetic code suggested that all extant forms of life use the same genetic code. This early presumption has subsequently been challenged by the discovery of deviations of the universal genetic code in prokaryotes, eukaryotic nuclear genomes and mitochondrial genomes. These studies have revealed that the genetic code is still evolving despite strong negative forces working against the fixation of mutations that result in codon reassignment. Recent data from in vitro, in vivo and in silico comparative genomics studies are revealing significant, previously overlooked links between modified nucleosides in tRNAs, genetic code ambiguity, genome base composition, codon usage and codon reassignment.
Peer review: yes
DOI: 10.1016/j.tig.2003.12.009
ISSN: 0168-9525
Appears in Collections:CESAM - Artigos
DBio - Artigos

Files in This Item:
File Description SizeFormat 
Santos et al. 2004.pdf467.07 kBAdobe PDFrestrictedAccess

Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.