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Title: Genotoxic and biochemical responses in caged eel (Anguilla anguilla L.) after short-term exposure to harbour waters
Author: Maria, V. L.
Correia, A. C.
Santos, M. A.
Keywords: Genotoxicity
DNA strand breaks
Anguilla anguilla L.
Issue Date: Jan-2004
Publisher: Elsevier
Abstract: European eel (Anguilla anguilla L.) were caged and exposed in situ for 8 and 48 h to the Aveiro offward fishing harbour water (HW) and to clean seawater under laboratory conditions (Control). Eel liver biotransformation (Phase I) was measured as ethoxyresorufin-O-deethylase (EROD) activity, cytochrome P450 (P450) and glutathione S-transferase (GST) activity (Phase II). Genotoxic responses were determined as blood, liver and kidney DNA strand breaks as well as erythrocytic nuclear abnormalities (ENAs). HW failed to significant increase liver EROD, GST activities and ENA frequency. Nevertheless, P450 content was significantly increased after 8 and 48 h exposure. Genotoxicity measured as DNA integrity decrease was found in blood after 8 and 48 h exposure to HW, whereas in liver and kidney, it was observed after 48 h exposure to HW. Blood, kidney and liver genotoxicity may be due to the presence of polycyclic aromatic hydrocarbons (PAHs) which are genotoxic compounds and the main HW organic contaminants.
Peer review: yes
DOI: 10.1016/S0160-4120(03)00057-6
ISSN: 0160-4120
Appears in Collections:CESAM - Artigos
DBio - Artigos

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