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Title: The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability
Author: Pimentel, Catarina
Vicente, Cristina
Menezes, Regina Andrade
Caetano, Soraia
Carreto, Laura
Rodrigues-Pousada, Claudina
Issue Date: 2012
Publisher: Public Library of Science
Abstract: The budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes directly or indirectly involved in iron homeostasis showed altered expression and the relevance of these changes are discussed. Microarray analyses were also performed to identify new targets of the iron responsive factor Yap5. Besides the iron vacuolar transporter CCC1, Yap5 also controls the expression of glutaredoxin GRX4, previously known to be involved in the regulation of Aft1 nuclear localization. Consistently, we show that in the absence of Yap5 Aft1 nuclear exclusion is slightly impaired. These studies provide further evidence that cells control iron homeostasis by using multiple pathways.
Peer review: yes
DOI: 10.1371/journal.pone.0037434
Appears in Collections:CESAM - Artigos
DBio - Artigos

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