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|Title:||Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost|
Castro, L. F. C.
Peroxisome proliferator activated receptors
|Abstract:||Dietary long chain polyunsaturated fatty acids (FA) have been recognized of crucial importance in early development of vertebrates, contributing to the impressive morphological and physiological changes both as building blocks and to energy production. The importance of lipids along development depends on ontogenetic, phylogenetic and environmental parameters. The expression patterns of FA metabolism genes have not been characterized in developing fish embryos nor compared to lipid class profiles. Full lipid metabolism only occurred after hatching, as revealed by alterations in lipid profiles and FA gene expression. Nonetheless, transcriptional changes of some FA genes were already present in embryos at notochord formation. Many genes displayed an expression profile opposed to the decrease of lipids along the development, while others responded solely to starvation. Transcription of most genes involved in FA metabolism had a strong correlation to PPARs' mRNA levels (α1, α2, β, γ). The comparison of mRNA expression of the genes with the lipid profiles produced new insights into the FA metabolism and regulation during the development of turbot larvae, providing the basis for future studies including comparative approaches with other vertebrate species.|
|Appears in Collections:||CESAM - Artigos|
DBio - Artigos
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|Cunha et al. - 2013 - Dynamics of PPARs, fatty acid metabolism genes and.pdf||1.87 MB||Adobe PDF|
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