Please use this identifier to cite or link to this item:
Title: Lycopene from tomatoes: vesicular nanocarrier formulations for dermal delivery
Author: Ascenso, Andreia
Pinho, Sónia
Eleutério, Carla
Praça, Fabíola Garcia
Bentley, Maria Vitória Lopes Badra
Oliveira, Helena
Santos, Conceição
Silva, Olga
Simões, Sandra
Keywords: Anthralin-induced dermatitis
Cellular uptake
Extraction method
Issue Date: 2013
Publisher: American Chemical Society
Abstract: This experimental work aimed to develop a simple, fast, economic, and environmentally friendly process for the extraction of lycopene from tomato and incorporate this lycopene-rich extract into ultradeformable vesicular nanocarriers suitable for topical application. Lycopene extraction was conducted without a cosolvent for 30 min. The extracts were analyzed and incorporated in transfersomes and ethosomes. These formulations were characterized, and the cellular uptake was observed by confocal microscopy. Dermal delivery of lycopene formulations was tested under in vitro and in vivo conditions. Lycopene extraction proved to be quite safe and selective. The vesicular formulation was taken up by the cells, being more concentrated around the nucleus. Epicutaneous application of lycopene formulations decreased the level of anthralin-induced ear swelling by 97 and 87%, in a manner nonstatistically different from the positive control. These results support the idea that the lycopene-rich extract may be a good alternative to the expensive commercial lycopene for incorporation into advanced topical delivery systems.
Peer review: yes
DOI: 10.1021/jf401368w
ISSN: 0021-8561
Appears in Collections:CESAM - Artigos
DBio - Artigos

Files in This Item:
File Description SizeFormat 
Ascenso et al. - 2013 - Lycopene from Tomatoes Vesicular Nanocarrier Form.pdf1.08 MBAdobe PDFrestrictedAccess

Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.