Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/23081
Title: Protein mistranslation: friend or foe?
Author: Ribas de Pouplana, Liuís
Santos, Manuel A. S.
Zhu, Jun-Hao
Farabaugh, Philip J.
Javid, Babak
Issue Date: 2014
Publisher: Elsevier
Abstract: The translation of genes into functional proteins involves error. Mistranslation is a known cause of disease, but, surprisingly, recent studies suggest that certain organisms from all domains of life have evolved diverse pathways that increase their tolerance of translational error. Although the reason for these high error rates are not yet clear, evidence suggests that increased mistranslation may have a role in the generation of diversity within the proteome and other adaptive functions. Error rates are regulated, and there appears to be an optimal mistranslation rate that varies by organism and environmental condition. Advances in unbiased interrogation of error types and experiments involving wild organisms may help our understanding of the potentially adaptive roles for protein translation errors.
Peer review: yes
URI: http://hdl.handle.net/10773/23081
DOI: 10.1016/j.tibs.2014.06.002
ISSN: 0968-0004
Appears in Collections:CESAM - Artigos
DBio - Artigos

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