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Title: Marine microorganism-invertebrate assemblages: perspectives to solve the "supply problem" in the initial steps of drug discovery
Author: Leal, Miguel Costa
Sheridan, Christopher
Osinga, Ronald
Dioníasio, Gisela
Rocha, Rui Jorge Miranda
Silva, Bruna
Rosa, Rui
Calado, Ricardo
Keywords: Aquaculture
Marine invertebrates
Marine natural products
Microbial symbionts
Issue Date: 2014
Publisher: MDPI
Abstract: The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the "blue gold" in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts.
Peer review: yes
DOI: 10.3390/md12073929
ISSN: 1660-3397
Appears in Collections:CESAM - Artigos
DBio - Artigos

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