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Title: DNA and chromosomal damage induced in fish (Anguilla anguilla L.) by aminomethylphosphonic acid (AMPA)-the major environmental breakdown product of glyphosate
Author: Guilherme, S.
Santos, M. A.
Gaivão, I.
Pacheco, M.
Keywords: AMPA
DNA lesion-specific repair enzymes
Issue Date: 2014
Publisher: Springer
Abstract: The assessment of the direct impact of breakdown products of pesticide components on aquatic wildlife is ecotoxicologically relevant, but frequently disregarded. In this context, the evaluation of the genotoxic hazard posed by aminomethylphosphonic acid (AMPA-the major natural degradation product of glyphosate) to fish emerges as a critical but unexplored issue. Hence, the main goal of the present research was to assess the AMPA genotoxic potential to fish following short-term exposures (1 and 3 days) to environmentally realistic concentrations (11.8 and 23.6 μg L(-1)), using the comet and erythrocytic nuclear abnormalities (ENA) assays, as reflecting different levels of damage, i.e. DNA and chromosomal damage, respectively. Overall, the present findings pointed out the genotoxic hazard of AMPA to fish and, subsequently, the importance of including it in future studies concerning the risk assessment of glyphosate-based herbicides in the water systems.
Peer review: yes
DOI: 10.1007/s11356-014-2803-1
ISSN: 0944-1344
Appears in Collections:CESAM - Artigos
DBio - Artigos

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