Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/20836
Title: Synthesis and biological evaluation of ternary silver compounds bearing N,N-chelating ligands and thiourea: X-ray structure of [{Ag(bpy) (mu-tu)}(2)](NO3)(2) (bpy=2,2 '-bipyridine; tu = thiourea)
Author: Segura, Daniel F.
Netto, Adelino V. G.
Frem, Regina C. G.
Mauro, Antonio E.
da Silva, Patricia B.
Fernandes, Jose A.
Paz, Filipe A. A.
Dias, Amanda L. T.
Silva, Naiara C.
de Almeida, Eduardo T.
Marques, Marcos J.
de Almeida, Leticia
Alves, Karina F.
Pavan, Fernando R.
de Souza, Paula C.
de Barros, Heloisa B.
Leite, Clarice Q. F.
Keywords: ANTIMICROBIAL ACTIVITIES
CRYSTAL-STRUCTURES
IN-VITRO
SPECTROSCOPIC CHARACTERIZATION
TRIPHENYLPHOSPHINE LIGANDS
MYCOBACTERIUM-TUBERCULOSIS
ANTIMYCOBACTERIAL ACTIVITY
LEISHMANICIDAL ACTIVITY
SUBSTITUTED THIOUREAS
COORDINATION POLYMERS
Issue Date: 2014
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Abstract: Compounds [{Ag(phen)(mu-tu)}(2)](NO3)(2) (1), [{Ag(phen)(mu-tu)}(2)](CF3SO3)(2) (2), [{Ag(bpy)(mu-tu)}(2)](NO3)(2) (3) (where phen = 1,10-phenanthroline; bpy = 2,2'-bipyridine; tu = thiourea) were prepared by reacting the appropriate AgX salt (X- = NO3-, CF3SO3-), the N,N-chelating ligand (phen or bpy) and thiourea in a ca. 1:1:2 M ratio, respectively. The silver(l) complexes were characterized by elemental analysis, infrared (IR), H-1 and C-13 NMR spectroscopies, MS/ESI and conductivity measurements. The IR and NMR data were consistent with the presence of chelating phen (1 and 2) and bpy (3) ligands and demonstrated the S-coordination mode of thiourea. The crystal and molecular structures of compound [{Ag(bpy)(mu-tu)}(2)] (NO3)(2) (3) were determined by single-crystal X-ray diffraction. The complexes 1-3 were screened for their in vitro antimycobacterial (Mycobacterium tuberculosis), antileishmanial (Leishmania (L) amazonensis), antibacterial (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa), antifungal activities (Candida albi cans, Candida tropicalis, Candida krusei). (C) 2014 Elsevier Ltd. All rights reserved.
Peer review: yes
URI: http://hdl.handle.net/10773/20836
DOI: 10.1016/j.poly.2014.05.004
ISSN: 0277-5387
Publisher Version: 10.1016/j.poly.2014.05.004
Appears in Collections:CICECO - Artigos



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