Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10773/20524
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Pinto, Moises L. | pt |
dc.contributor.author | Fernandes, Ana Cristina | pt |
dc.contributor.author | Antunes, Fernando | pt |
dc.contributor.author | Pires, Joao | pt |
dc.contributor.author | Rocha, Joao | pt |
dc.date.accessioned | 2017-12-07T19:50:07Z | - |
dc.date.issued | 2016 | pt |
dc.identifier.issn | 1387-1811 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/20524 | - |
dc.description.abstract | Exogenous administration of nitric oxide may be a therapy for several pathologies because this molecule regulates many biological systems. Here, the storage and release of NO by microporous titanosilicate ETS-10 and samples where the silicon was substituted by aluminium (ETAS-10) or gallium (ETGS-10) are studied. The Al- and Ga-doped materials exhibit an increase in the storage capacity of 95% and 55%, respectively, the highest values observed, so far, for microporous titanosilicates. ETAS-10 releases more NO and ETGS-10 almost the same amount as ETS-10. In ETAS-10 and ETGS-10, the irreversibly adsorbed NO amount increases relatively to ETS-10. Tests of NO release in haemoglobin solutions indicate that biologically relevant amounts are release and that ETS-10 and ETGS-10 display a release slower than ETAS-10, more adequate for a sustained delivery. Cytotoxicity studies show that the samples have very low toxicity (cell viability above 87%, after 72 h) at high concentration (0.45 mg cm(-3)). Tests at variable ETS-10 concentration further confirm the low cytotoxicity of this material, even at high concentrations (up to 1.8 mg cm(-3)). (C) 2016 Elsevier Inc. All rights reserved. | pt |
dc.language.iso | eng | pt |
dc.publisher | ELSEVIER SCIENCE BV | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147332/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147223/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147264/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F72058%2F2010/PT | pt |
dc.rights | restrictedAccess | por |
dc.subject | HELA CANCER-CELLS | pt |
dc.subject | DRUG-DELIVERY | pt |
dc.subject | SLOW-RELEASE | pt |
dc.subject | ZEOLITE STRUCTURES | pt |
dc.subject | SURFACE-PROPERTIES | pt |
dc.subject | NANOPARTICLES | pt |
dc.subject | CYTOTOXICITY | pt |
dc.subject | ADSORPTION | pt |
dc.subject | NO | pt |
dc.subject | AVOIDANCE | pt |
dc.title | Storage and delivery of nitric oxide by microporous titanosilicate ETS-10 and Al and Ga substituted analogues | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 83 | pt |
degois.publication.lastPage | 89 | pt |
degois.publication.title | MICROPOROUS AND MESOPOROUS MATERIALS | pt |
degois.publication.volume | 229 | pt |
dc.date.embargo | 10000-01-01 | - |
dc.relation.publisherversion | 10.1016/j.micromeso.2016.04.021 | pt |
dc.identifier.doi | 10.1016/j.micromeso.2016.04.021 | pt |
Aparece nas coleções: | CICECO - Artigos |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Storage and delivery of nitric oxide by microporous titanosilicate ETS-10 and Al and Ga substituted analogues_10.1016j.micromeso.2016.04.021.pdf | 789.69 kB | Adobe PDF |
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