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http://hdl.handle.net/10773/20524
Title: | Storage and delivery of nitric oxide by microporous titanosilicate ETS-10 and Al and Ga substituted analogues |
Author: | Pinto, Moises L. Fernandes, Ana Cristina Antunes, Fernando Pires, Joao Rocha, Joao |
Keywords: | HELA CANCER-CELLS DRUG-DELIVERY SLOW-RELEASE ZEOLITE STRUCTURES SURFACE-PROPERTIES NANOPARTICLES CYTOTOXICITY ADSORPTION NO AVOIDANCE |
Issue Date: | 2016 |
Publisher: | ELSEVIER SCIENCE BV |
Abstract: | Exogenous administration of nitric oxide may be a therapy for several pathologies because this molecule regulates many biological systems. Here, the storage and release of NO by microporous titanosilicate ETS-10 and samples where the silicon was substituted by aluminium (ETAS-10) or gallium (ETGS-10) are studied. The Al- and Ga-doped materials exhibit an increase in the storage capacity of 95% and 55%, respectively, the highest values observed, so far, for microporous titanosilicates. ETAS-10 releases more NO and ETGS-10 almost the same amount as ETS-10. In ETAS-10 and ETGS-10, the irreversibly adsorbed NO amount increases relatively to ETS-10. Tests of NO release in haemoglobin solutions indicate that biologically relevant amounts are release and that ETS-10 and ETGS-10 display a release slower than ETAS-10, more adequate for a sustained delivery. Cytotoxicity studies show that the samples have very low toxicity (cell viability above 87%, after 72 h) at high concentration (0.45 mg cm(-3)). Tests at variable ETS-10 concentration further confirm the low cytotoxicity of this material, even at high concentrations (up to 1.8 mg cm(-3)). (C) 2016 Elsevier Inc. All rights reserved. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/20524 |
DOI: | 10.1016/j.micromeso.2016.04.021 |
ISSN: | 1387-1811 |
Publisher Version: | 10.1016/j.micromeso.2016.04.021 |
Appears in Collections: | CICECO - Artigos |
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Storage and delivery of nitric oxide by microporous titanosilicate ETS-10 and Al and Ga substituted analogues_10.1016j.micromeso.2016.04.021.pdf | 789.69 kB | Adobe PDF |
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