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http://hdl.handle.net/10773/19950
Title: | Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders |
Author: | Shi, Fa-Nian Almeida, Jose C. Helguero, Luisa A. Fernandes, Maria H. V. Knowles, Jonathan C. Rocha, Joao |
Keywords: | OCTACALCIUM PHOSPHATE PROTON CONDUCTIVITY APATITE-FORMATION VITAMIN-D BISPHOSPHONATES BIOACTIVITY MECHANISM HEALTH MILK |
Issue Date: | 2015 |
Publisher: | AMER CHEMICAL SOC |
Abstract: | Two new examples of uncommon three-dimensional Ca-bearing metal organic frameworks, [Ca(H2O)(3)(HPXBP)] (CaP1) and [Ca-2(H2O)(2)(HPXBP)(1.5)] (CaP2) (PXBP: p-xylylenebisphosphonate), were prepared and their structures characterized by single crystal X-ray diffraction. CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination sphere on one side of the Ca atom, while CaP2 crystallizes in the triclinic P (1) over bar space group, with two crystallographic unique Ca atoms, each coordinated by a single water molecule. In contrast with CaP2, which exhibits very low bioactivity, CaP1 readily precipitates bone-precursor phases (octacalcium phosphate, OCP, and hydroxyapatite) in SBF solutions. Moreover, studies with MG63 osteoblast-like cells indicate that CaP1 is not toxic and stimulates bone mineralization and, thus, holds considerable potential for treating bone diseases, such as osteoporosis. |
Peer review: | yes |
URI: | http://hdl.handle.net/10773/19950 |
DOI: | 10.1021/acs.inorgchem.5b01634 |
ISSN: | 0020-1669 |
Publisher Version: | 10.1021/acs.inorgchem.5b01634 |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders_10.1021acs.inorgchem.5b01634.pdf | 1.89 MB | Adobe PDF |
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