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|Title:||Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders|
Almeida, Jose C.
Helguero, Luisa A.
Fernandes, Maria H. V.
Knowles, Jonathan C.
|Publisher:||AMER CHEMICAL SOC|
|Abstract:||Two new examples of uncommon three-dimensional Ca-bearing metal organic frameworks, [Ca(H2O)(3)(HPXBP)] (CaP1) and [Ca-2(H2O)(2)(HPXBP)(1.5)] (CaP2) (PXBP: p-xylylenebisphosphonate), were prepared and their structures characterized by single crystal X-ray diffraction. CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination sphere on one side of the Ca atom, while CaP2 crystallizes in the triclinic P (1) over bar space group, with two crystallographic unique Ca atoms, each coordinated by a single water molecule. In contrast with CaP2, which exhibits very low bioactivity, CaP1 readily precipitates bone-precursor phases (octacalcium phosphate, OCP, and hydroxyapatite) in SBF solutions. Moreover, studies with MG63 osteoblast-like cells indicate that CaP1 is not toxic and stimulates bone mineralization and, thus, holds considerable potential for treating bone diseases, such as osteoporosis.|
|Appears in Collections:||CICECO - Artigos|
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|Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders_10.1021acs.inorgchem.5b01634.pdf||1.89 MB||Adobe PDF|
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