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http://hdl.handle.net/10773/19950
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DC Field | Value | Language |
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dc.contributor.author | Shi, Fa-Nian | pt |
dc.contributor.author | Almeida, Jose C. | pt |
dc.contributor.author | Helguero, Luisa A. | pt |
dc.contributor.author | Fernandes, Maria H. V. | pt |
dc.contributor.author | Knowles, Jonathan C. | pt |
dc.contributor.author | Rocha, Joao | pt |
dc.date.accessioned | 2017-12-07T19:30:25Z | - |
dc.date.issued | 2015 | pt |
dc.identifier.issn | 0020-1669 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/19950 | - |
dc.description.abstract | Two new examples of uncommon three-dimensional Ca-bearing metal organic frameworks, [Ca(H2O)(3)(HPXBP)] (CaP1) and [Ca-2(H2O)(2)(HPXBP)(1.5)] (CaP2) (PXBP: p-xylylenebisphosphonate), were prepared and their structures characterized by single crystal X-ray diffraction. CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination sphere on one side of the Ca atom, while CaP2 crystallizes in the triclinic P (1) over bar space group, with two crystallographic unique Ca atoms, each coordinated by a single water molecule. In contrast with CaP2, which exhibits very low bioactivity, CaP1 readily precipitates bone-precursor phases (octacalcium phosphate, OCP, and hydroxyapatite) in SBF solutions. Moreover, studies with MG63 osteoblast-like cells indicate that CaP1 is not toxic and stimulates bone mineralization and, thus, holds considerable potential for treating bone diseases, such as osteoporosis. | pt |
dc.language.iso | eng | pt |
dc.publisher | AMER CHEMICAL SOC | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147332/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/119994/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/118346/PT | pt |
dc.rights | restrictedAccess | por |
dc.subject | OCTACALCIUM PHOSPHATE | pt |
dc.subject | PROTON CONDUCTIVITY | pt |
dc.subject | APATITE-FORMATION | pt |
dc.subject | VITAMIN-D | pt |
dc.subject | BISPHOSPHONATES | pt |
dc.subject | BIOACTIVITY | pt |
dc.subject | MECHANISM | pt |
dc.subject | HEALTH | pt |
dc.subject | MILK | pt |
dc.title | Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 9929 | pt |
degois.publication.issue | 20 | pt |
degois.publication.lastPage | 9935 | pt |
degois.publication.title | INORGANIC CHEMISTRY | pt |
degois.publication.volume | 54 | pt |
dc.date.embargo | 10000-01-01 | - |
dc.relation.publisherversion | 10.1021/acs.inorgchem.5b01634 | pt |
dc.identifier.doi | 10.1021/acs.inorgchem.5b01634 | pt |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders_10.1021acs.inorgchem.5b01634.pdf | 1.89 MB | Adobe PDF |
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