New platinum(II)-bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSA

Abstract

A simple methodology giving access to the metal-free corroles of trans-A(2)B type, 5,15-bis (pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-(4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure. (C) 2015 Elsevier Inc. All rights reserved.