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http://hdl.handle.net/10773/19505
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Iglesias, Bernardo A. | pt |
dc.contributor.author | Barata, Joana F. B. | pt |
dc.contributor.author | Pereira, Patricia M. R. | pt |
dc.contributor.author | Girao, Henrique | pt |
dc.contributor.author | Fernandes, Rosa | pt |
dc.contributor.author | Tome, Joao P. C. | pt |
dc.contributor.author | Neves, Maria G. P. M. S. | pt |
dc.contributor.author | Cavaleiro, Jose A. S. | pt |
dc.date.accessioned | 2017-12-07T19:15:03Z | - |
dc.date.issued | 2015 | pt |
dc.identifier.issn | 0162-0134 | pt |
dc.identifier.uri | http://hdl.handle.net/10773/19505 | - |
dc.description.abstract | A simple methodology giving access to the metal-free corroles of trans-A(2)B type, 5,15-bis (pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-(4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure. (C) 2015 Elsevier Inc. All rights reserved. | pt |
dc.language.iso | eng | pt |
dc.publisher | ELSEVIER SCIENCE INC | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147415/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147332/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F63237%2F2009/PT | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F85941%2F2012/PT | pt |
dc.rights | restrictedAccess | por |
dc.subject | HUMAN SERUM-ALBUMIN | pt |
dc.subject | FREE-BASE CORROLES | pt |
dc.subject | MESOSUBSTITUTED CORROLES | pt |
dc.subject | MANGANESE(III) CORROLE | pt |
dc.subject | PLATINUM COMPLEXES | pt |
dc.subject | FLUORESCENCE BEHAVIOR | pt |
dc.subject | NUCLEASE ACTIVITY | pt |
dc.subject | COUPLING REACTION | pt |
dc.subject | CHARGED CORROLES | pt |
dc.subject | IN-VITRO | pt |
dc.title | New platinum(II)-bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSA | pt |
dc.type | article | pt |
dc.peerreviewed | yes | pt |
ua.distribution | international | pt |
degois.publication.firstPage | 32 | pt |
degois.publication.lastPage | 41 | pt |
degois.publication.title | JOURNAL OF INORGANIC BIOCHEMISTRY | pt |
degois.publication.volume | 153 | pt |
dc.date.embargo | 10000-01-01 | - |
dc.relation.publisherversion | 10.1016/j.jinorgbio.2015.08.016 | pt |
dc.identifier.doi | 10.1016/j.jinorgbio.2015.08.016 | pt |
Appears in Collections: | CICECO - Artigos |
Files in This Item:
File | Description | Size | Format | |
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New platinum(II)-bipyridyl corrole complexes Synthesis characterization and binding studies with DNA and HSA_10.1016j.jinorgbio.2015.08.016.pdf | 946.02 kB | Adobe PDF | ![]() |
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