Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/19505
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dc.contributor.authorIglesias, Bernardo A.pt
dc.contributor.authorBarata, Joana F. B.pt
dc.contributor.authorPereira, Patricia M. R.pt
dc.contributor.authorGirao, Henriquept
dc.contributor.authorFernandes, Rosapt
dc.contributor.authorTome, Joao P. C.pt
dc.contributor.authorNeves, Maria G. P. M. S.pt
dc.contributor.authorCavaleiro, Jose A. S.pt
dc.date.accessioned2017-12-07T19:15:03Z-
dc.date.issued2015pt
dc.identifier.issn0162-0134pt
dc.identifier.urihttp://hdl.handle.net/10773/19505-
dc.description.abstractA simple methodology giving access to the metal-free corroles of trans-A(2)B type, 5,15-bis (pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-(4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure. (C) 2015 Elsevier Inc. All rights reserved.pt
dc.language.isoengpt
dc.publisherELSEVIER SCIENCE INCpt
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147415/PTpt
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147332/PTpt
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F63237%2F2009/PTpt
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F85941%2F2012/PTpt
dc.rightsrestrictedAccesspor
dc.subjectHUMAN SERUM-ALBUMINpt
dc.subjectFREE-BASE CORROLESpt
dc.subjectMESOSUBSTITUTED CORROLESpt
dc.subjectMANGANESE(III) CORROLEpt
dc.subjectPLATINUM COMPLEXESpt
dc.subjectFLUORESCENCE BEHAVIORpt
dc.subjectNUCLEASE ACTIVITYpt
dc.subjectCOUPLING REACTIONpt
dc.subjectCHARGED CORROLESpt
dc.subjectIN-VITROpt
dc.titleNew platinum(II)-bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSApt
dc.typearticlept
dc.peerreviewedyespt
ua.distributioninternationalpt
degois.publication.firstPage32pt
degois.publication.lastPage41pt
degois.publication.titleJOURNAL OF INORGANIC BIOCHEMISTRYpt
degois.publication.volume153pt
dc.date.embargo10000-01-01-
dc.relation.publisherversion10.1016/j.jinorgbio.2015.08.016pt
dc.identifier.doi10.1016/j.jinorgbio.2015.08.016pt
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