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Title: Assessment of cytotoxicity and oxidative stress induced by titanium oxide nanoparticles on Chinook salmon cells
Author: Srikanth, Koigoora
Pereira, Eduarda
Ahmad, Iqbal
Rao, Janapala Venkateswara
Duarte, Armando C.
Keywords: Chinook salmon
Titaniumoxide nanoparticles
Oxidative stress
Lipid peroxidation
Issue Date: 2015
Publisher: Springer
Abstract: Titanium oxide nanoparticles (TiO2 NPs) have received wide attention in diverse application, but the potential impact of these nanomaterials on the environment, aquatic life and especially on fish cell lines is lacking. The present study aimed to investigate the cytotoxicity and oxidative stress induced by TiO2 NPs on Chinook salmon cells derived from Oncorhynchus tshawytscha embryos (CHSE-214). The The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide] and neutral red (NR) assays in CHSE-214 cells exposed to TiO2 NPs revealed concentration-dependent cytotoxic effect in the range of 10 to 60 μg/ml for 24 h. CHSE-214 cells exposed to TiO2 NPs (10-60 μg/ml) exhibited significant decline in superoxide dismutase (SOD), catalase (CAT) glutathione (GSH) content and increased lipid peroxidation (LPO) in a concentration-dependent manner. TiO2 NPs induced cytotoxicity and oxidative stress in CHSE-214 cells which serve as a base line studies for future studies.
Peer review: yes
DOI: 10.1007/s11356-015-4740-z
ISSN: 0944-1344
Appears in Collections:CESAM - Artigos
DQ - Artigos

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