Please use this identifier to cite or link to this item: http://hdl.handle.net/10773/13195
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dc.contributor.authorNogueira, P.pt
dc.contributor.authorPacheco, M.pt
dc.contributor.authorPereira, M. L.pt
dc.contributor.authorMendo, S.pt
dc.contributor.authorRotchell, J. M.pt
dc.date.accessioned2015-01-20T11:26:17Z-
dc.date.issued2010-05-
dc.identifier.issn0269-7491pt
dc.identifier.urihttp://hdl.handle.net/10773/13195-
dc.description.abstractThe responses of Dicentrarchus labrax and Liza aurata to aquatic pollution were assessed in a contaminated coastal lagoon, using both traditional and novel biomarkers combined. DNA damage, assessed by comet assay, was higher in both fish species from the contaminated sites, whereas levels of cytochrome P450 1A1 gene expression were not significantly altered. The liver histopathological analysis also revealed significant lesions in fish from contaminated sites. Alterations in ras and xpf genes were analysed and additional pollutant-responsive genes were identified. While no alterations were found in ras gene, a downregulation of xpf gene was observed in D. labrax from a contaminated site. Suppression subtractive hybridization applied to D. labrax collected at a contaminated site, revealed altered expression in genes involved in energy metabolism, immune system activity and antioxidant response. The approach and results reported herein demonstrate the utility of anchoring traditional biomarker responses alongside novel biomarker responses.pt
dc.language.isoengpt
dc.publisherElsevierpt
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F16763%2F2004/PTpt
dc.rightsrestrictedAccesspor
dc.subjectPollutionpt
dc.subjectBiomarkerpt
dc.subjectToxicologypt
dc.subjectFishpt
dc.titleAnchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contaminationpt
dc.typearticlept
dc.peerreviewedyespt
ua.distributioninternationalpt
ua.event.titleEnvironmental Pollution-
degois.publication.firstPage1783pt
degois.publication.issue5pt
degois.publication.lastPage1790pt
degois.publication.titleEnvironmental Pollutionpt
degois.publication.volume158pt
dc.date.embargo10000-01-01-
dc.identifier.doi10.1016/j.envpol.2009.11.007pt
Appears in Collections:CESAM - Artigos
Ria de Aveiro - Artigos

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